Bree Walker was born in 1953 and raised in the state of Minnesota near the Iowa border. She inherited a rare genetic condition called ectrodactyly. Traditionally referred to as "lobster-claw syndrome," the condition fused together the digits of her hands and feet into claw-like appendages. Much of her on-camera career in the '80s and '90s was spent with her hands hidden beneath a news desk. In 2005 Walker starred as one of the sideshow attractions on the dark HBO drama Carnivale. Walke played the glamorous, seductive "Scorpion Queen" Sabina, who was married to a half-man, half-woman named Bert/Bertha and was previously wed to dwarfed Carnivale proprietor Samson.

Walker, in real life, has been married and divorced three times. Her surname is taken from her second husband. She has one child with that husband, and one with her third ex-husband, Jim Lampley.Walker and her third husband, NBC and HBO sportscaster Jim Lampley, jointly run Crystal Spring Productions, a film production company. She is also a contributing writer for New Image magazine. Walker resides in Del Mar, California with her children, both of whom also have ectrodactyly.

Walker currently hosts a progressive talk show on KTLK AM 1150 in Los Angeles on Saturdays from 2 to 4 p.m. Pacific Time.

On June 8, 2007 Brad Friedman of The BRAD BLOG [1] broke the news that Walker had purchased Cindy Sheehan's 5-acre (20,000 m2) "Camp Casey" site in Crawford, Texas for $87,000, in response to Sheehan's May 26, 2007 announcement that she would be selling the site and ending her antiwar activities. Walker plans to preserve the property as a peace memorial and garden, and keep it open to antiwar protesters. Sheehan handed the deed to Walker during her June 9, 2007 broadcast of The Bree Walker show.

Walker also is a painter, a sculptor and an accomplished equestrian.